In a study published in NEJM regarding mild traumatic brain injury in US
Soldiers returning from Iraq, which one of the following was most
strongly associated with the development of PTSD?
A.
Exposure to multiple blasts.
B.
High combat intensity.
C.
Hospitalization.
D.
Witnessing death
More than 1.5 million U.S. military personnel have deployed to Iraq or
Afghanistan since the start of military operations in 2001. Because of
improved protective equipment, a higher percentage of soldiers are
surviving injuries that would have been fatal in previous wars. Head and
neck injuries, including severe brain trauma, have been reported in one
quarter of service members who have been evacuated from Iraq and
Afghanistan. Concern has been emerging about the possible long-term
effect of mild traumatic brain injury, or concussion, characterized by
brief loss of consciousness or altered mental status, as a result of
deployment-related head injuries, particularly those resulting from
proximity to blast explosions. Traumatic brain injury has been labeled a
signature injury of the wars in Iraq and Afghanistan
The study questionnaire asked soldiers whether they had been injured
during their deployment by a blast or explosion, a bullet, a fragment or
shrapnel, a fall, a vehicle accident, or other means and whether the
injury involved the head. A soldier was considered to have had a mild
traumatic brain injury if any of three questions - regarding "losing
consciousness (knocked out)," "being dazed, confused, or `seeing
stars,'" or "not remembering the injury" - elicited a positive response.
These questions were based on definitions from the Centers for Disease
Control and Prevention and the World Health Organization that were
adapted by the Defense and Veterans Brain Injury Center working group
for military-wide use. The question regarding loss of consciousness was
analyzed separately to determine whether it was a stronger predictor
than the two other questions pertaining to altered mental status, the
results of which were combined. Soldiers who reported any injury that
did not involve altered mental status or losing consciousness served as
the reference group for all analyses.
PTSD was strongly associated with mild traumatic brain injury. Overall,
43.9% of soldiers who reported loss of consciousness met the criteria
for PTSD, as compared with 27.3% of those with altered mental status,
16.2% of those with other injuries, and 9.1% of those with no injuries.
In a logistic-regression model that included age, military rank, sex,
hospitalization or no hospitalization, mechanism of injury (blast or
other mechanisms), level of combat intensity, exposure or nonexposure to
multiple blasts from improvised explosive devices, and type of injury
(loss of consciousness vs. other injuries), only loss of consciousness
and combat intensity remained significantly associated with PTSD (odds
ratio for loss of consciousness, 2.98; 95% confidence interval [CI],
1.70 to 5.24; odds ratio for top quartile of combat intensity vs. lowest
quartile, 11.58; 95% CI, 2.99 to 44.83). Injury with loss of
consciousness was also independently associated with major depression
(odds ratio, 3.67; 95% CI, 1.65 to 8.16). Similarly, injuries associated
with altered mental status (as compared with other injuries) and combat
intensity were significantly associated with PTSD (but not with
depression) (odds ratio for injuries with altered mental status, 1.78;
95% CI, 1.13 to 2.81; odds ratio for combat intensity, 6.63; 95% CI,
2.23 to 19.76).
Answer: B
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